c-Jun氨基末端激酶1/2/3 (phospho Thr183/Y185)多克隆抗體

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產(chǎn)品英文名稱	JNK1/2/3 (phospho Thr183/Y185) Polyclonal Antibody
免疫原	合成多肽：人源蛋白JNK1/2/3，磷酸化多肽，中心氨基酸為T183/Y185.
宿主	兔
反應(yīng)性	人, 大鼠, 小鼠, 雞
應(yīng)用	ELISA, IF, IHC-P, WB
實(shí)驗(yàn)建議	最佳的工作稀釋比例需要客戶摸索優(yōu)化。建議的起始嘗試的稀釋比為：WB：1:500-1:2000，ELISA：1:10000。尚未在其他應(yīng)用中測(cè)試。
克隆性	多克隆
純化工藝	使用表位特異性的免疫原，通過親和層析，從兔抗血清中親和純化抗體。

產(chǎn)品形式	液體溶液
濃度	1 mg/ml
儲(chǔ)存緩沖液	含有50％甘油，0.5％BSA和0.02％疊氮化鈉的PBS緩沖液。
保存建議	自發(fā)貨之日起，-20°C可穩(wěn)定保存1年。為最大限度的避免損失，請(qǐng)?jiān)诖蜷_管蓋之前融化抗體并離心。我們建議使用前分裝以避免反復(fù)凍融。
運(yùn)輸條件	藍(lán)冰運(yùn)輸
警告	本文列出的產(chǎn)品僅供研究使用，不適用于人類或臨床診斷。我們產(chǎn)品所推薦應(yīng)用，不是建議使用我們的產(chǎn)品去違反任何專利或許可證。對(duì)于使用本產(chǎn)品可能發(fā)生的專利侵權(quán)或其他違規(guī)行為，我們不承擔(dān)任何責(zé)任。

背景	Mitogen-activated protein kinase 8 encoded by MAPK8 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. Mitogen-activated protein kinase 8 is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. Mitogen-activated protein kinase 8 is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of MAPK8 suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported.
基因ID	5599/5601/5602
別名	MAPK8; JNK1; PRKM8; SAPK1; SAPK1C; Mitogen-activated protein kinase 8; MAP kinase 8; MAPK 8; JNK-46; Stress-activated protein kinase 1c; SAPK1c; Stress-activated protein kinase JNK1; c-Jun N-terminal kinase 1; MAPK9; JNK2; PRKM9; SAPK1A; Mi
其它	該抗體可檢測(cè)內(nèi)源蛋白
蛋白質(zhì)ID	P45983/P45984/P53779