CREB結(jié)合蛋白多克隆抗體

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產(chǎn)品英文名稱	CBP Polyclonal Antibody
免疫原	合成多肽：來(lái)源于C端的人源蛋白CBP. 氨基酸序列為： 2370-2450
宿主	兔
反應(yīng)性	人, 小鼠
應(yīng)用	ELISA, IF, IHC-P, WB
實(shí)驗(yàn)建議	最佳的工作稀釋比例需要客戶摸索優(yōu)化。建議的起始嘗試的稀釋比為：WB：1:500-1:2000，IHC-p：1:100-1:300，IF：1:200-1:1000，ELISA：1:10000。尚未在其他應(yīng)用中測(cè)試。
克隆性	多克隆
純化工藝	使用表位特異性的免疫原，通過(guò)親和層析，從兔抗血清中親和純化抗體。

產(chǎn)品形式	液體溶液
濃度	1 mg/ml
儲(chǔ)存緩沖液	含有50％甘油，0.5％BSA和0.02％疊氮化鈉的PBS緩沖液。
保存建議	自發(fā)貨之日起，-20°C可穩(wěn)定保存1年。為最大限度的避免損失，請(qǐng)?jiān)诖蜷_(kāi)管蓋之前融化抗體并離心。我們建議使用前分裝以避免反復(fù)凍融。
運(yùn)輸條件	藍(lán)冰運(yùn)輸
警告	本文列出的產(chǎn)品僅供研究使用，不適用于人類或臨床診斷。我們產(chǎn)品所推薦應(yīng)用，不是建議使用我們的產(chǎn)品去違反任何專利或許可證。對(duì)于使用本產(chǎn)品可能發(fā)生的專利侵權(quán)或其他違規(guī)行為，我們不承擔(dān)任何責(zé)任。

背景	CREBBP is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB， CREBBP is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. CREB binding protein has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. CREB binding protein acetylates both histone and non-histone proteins. CREB binding protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in CREBBP cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving CREBBP have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms.
基因ID	1387
別名	CREBBP; CBP; CREB-binding protein
其它	該抗體可檢測(cè)內(nèi)源蛋白
蛋白質(zhì)ID	Q92793
目標(biāo)條帶分子量（KD)	265